Faculty

Ender Ayanoglu
Professor, Electrical Engineering and Computer Science; Biomedical Engineering

Interests: audio signal processing and microphone arrays

Bruce G. Berg
Associate Professor, Cognitive Sciences

Interests: Audition, auditory attention, psychophysics of complex sounds, computational models of hearing, mathematical modeling of psychophysical and physiological auditory processes.

Elliot Botvinick
Assistant Professor, Biomedical Engineering; Beckman Laser Institute

Interests: mechanotransduction and mechanics of the microenvironment. His research focuses on the relationship between mechanical stresses on cells and molecular signaling, or cellular mechanotransduction. His research is relevant to hair cell function in the cochlea.

Anne L. Calof
Professor, Anatomy & Neurobiology

Interests: Molecular analysis of nervous system development and regeneration using transgenic mouse models, neural stem cells. Our research efforts are concentrated on understanding the nature and the targets of the signals that regulate the production of neurons by neuronal progenitor cells, during development and regeneration of the nervous system. To study these issues, we concentrate primarily on one system, in which the behavior of neuronal progenitor cells can be observed and manipulated easily: the olfactory epithelium (OE) of the mouse. We study the molecular regulation of neurogenesis and neuronal regeneration using a variety of approaches, including tissue culture, molecular biology, and the generation and analysis of transgenic mice.

Karina S. Cramer
Associate Professor , Neurobiology & Behavior

Interests: We study the cellular and molecular mechanisms that underlie formation of neural circuitry in the auditory system during embyrogenesis, and we examine how these mechanisms operate during plasticity. Our research addresses the development of circuitry in the auditory system. Information from the cochlea is transmitted to the brainstem through the auditory nerve. This input is arranged in a tonotopic manner, so that at each level of processing there is an orderly representation of best frequencies. We are studying the potential relationship between mechanisms of development and mechanisms of plasticity when connections in the auditory brainstem are altered following deafferentation.

Hamid Djalilian
Associate Professor , Department of Otolaryngology

Interests: We conduct research in several areas related to cochlear implants, acoustic neuroma, chronic ear disease, as well as ear, facial nerve and skull base conditions.

Wei Dong
Research Scientist, VA Loma Linda Healthcare System, Loma Linda, CA
Associate Research Professor, Department of Otolaryngology & Head and Neck Surgery, Loma Linda University Health, Loma Linda, CA

Interests: The signal processing of sound in the ear in both forward and reverse propagation directions under normal and pathological conditions. Our research program not only consists of providing direct observations of the activities of the outer, middle, and inner ear in vivo, but also contributes towards our understanding of the physical properties of the middle and inner ear for theoretical applications in the hearing field. The ultimate goal of our research is to guide and improve clinical diagnoses and treatment, with the aim of establishing improvements in the design of assistive-listening devices.

Michael D’Zmura
Professor, Cognitive Sciences

Interests: Vision, hearing, language, attention, speech, brain imaging, brain-computer interfaces, and multimodal processing.

Mary Fagan
Assistant Professor, Department of Communication Sciences and Disorders
Chapman University, Irvine, CA

Interests: Vocalization and Exploration in Hearing, Deaf, and Cochlear-Implanted Infants; Speech sound disorders

Ron Frostig
Professor, Neurobiology and Behavior

Interests: Our main research focus is the structure and function of sensory cortex including auditory, somatosensory and visual cortices, with special emphasis on plasticity. We believe that plasticity is a fundamental property that underlies both normal cortical function (from sensory processing to learning and memory) and cortical recovery from deprivation and injury. We therefore seek to investigate all of these aspects of plasticity within different sensory cortices.

Nicole Gage
Assistant Researcher, Cognitive Sciences

Interests: A central focus of our research is understanding the temporal dynamics of auditory language processing. We use a combination of brain imaging techniques such as anatomical magnetic resonance imaging (aMRI), Magnetoencephalography (MEG), electroencephalography (EEG), and auditory brainstem response (ABR) recordings. Much of our research is focused on understanding the development of auditory language cortex in children who are typically developing and in children with developmental disorder, such as autism. Another central aspect of our research is understanding the localization of specific language processes so that we may provide presurgical language mapping guidance for patients undergoing brain surgery.

Sunil Gandhi
Assistant Professor, Neurobiology and Behavior School of Biological Sciences

Interests: cortical plasticity, neural stem cells, inhibitory interneurons, hearing, vision, and neurobiology of learning and memory

Gregory S. Hickok
Professor, Cognitive Sciences

Interests: Neuroanatomy of language, neural plasticity, neuroimaging, cognitive neuroscience. We use a variety of methods (fMRI, lesion, TMS) to map brain systems supporting speech and language processing, in both hearing and deaf populations.

Leonard M. Kitzes
Professor, Anatomy & Neurobiology

Interests: Physiology and anatomy of brainstem auditory system. Developmental determinants of brainstem auditory system structure and function Auditory cortex function and structure.

Marjorie R. Leek
Senior Research Career Scientist, VA Loma Linda Healthcare System
Affiliate Research Professor, Department of Otolaryngology, Oregon Health & Science University

Interests: perception of complex sounds and speech by normal-hearing and hearing-impaired individuals; speech recognition in noise; modeling the auditory system; auditory attention; comparative auditory processes across species. We use psychoacoustic and electrophysiological measures of auditory perception to address issues related to speech processing by hearing-impaired and elderly individuals.

Hongzhe Li
Research Scientist, Loma Linda Veteran Association for Research & Education

Interests: Dr. Li’s research is primarily focused on inner ear protection, damage and repair, from a variety of ototoxic insults, including but not limited to noise, aminoglycoside antibiotics and antineoplastic cisplatin. Compound factors such as age, genetic variation and disease conditions are also considered.

Harrison Lin
Assistant Professor, Otology, Neurotology & Skull Base Surgery

Interests: work in several areas related to otology and neurotology, including cochlear implants and other auditory prostheses, acoustic neuroma, chronic ear disease, facial nerve disorders, balance disorders, tinnitus and hearing loss.

Brenda L Lonsbury-Martin
Professor, Otolaryngology, Loma Linda University Medical Center; Senior Research Scientist, VA Loma Linda Healthcare System

Interests: generation sources of otoacoustic emissions; establishing missions as a noninvasive assay of intracochlear activity; developing early detection tests for onset of noise-induced hearing loss and ototoxicity using otoacoustic emission cochleography; susceptibility/resistance of ear to sound-induced over-use and its genetic basis; differentiating the cochlear basis of hearing loss in patients with identical clinical audiograms; use-dependent changes in outer hair cell responses; pathophysiology and histopathology of cochlea. To these ends, the laboratory uses acoustic and physiological measures including otoacoustic emissions and evoked electrophysiological responses in both animal models and humans along with histopathological methods in animal models (chinchilla, gerbil, mouse, rabbit).

Virginia Mann
Professor, Cognitive Sciences

Interests: My research focuses on the development of reading ability and the perception of speech and involves undergraduate and graduate students as well as colleagues here and abroad. I am the director of an outreach program, HABLA, that seeks to promote school readiness through language-based interventions in the homes of over 350 socioeconomically and educationally disadvantaged preschoolers. I am also director of an outreach program, UCI Jumpstart, that is part of a national system for increasing English skills through college student mentoring of children in an after preschool program.

Matthew McHenry
Assistant Professor, Neurobiology & Behavior

Interests: We use a combination of theory and experimentation to understand how aquatic animals function mechanically. We then apply what we learn about biomechanics to questions about the development, evolution, and behavior of animals. The current focus of the lab is on understanding how zebrafish use their lateral line system to sense the flow of water around them.

Raju Metherate
Professor, Neurobiology & Behavior

Interests: Mechanisms of auditory cortex physiology, development and modulation. Our long-term goal is to understand the cellular basis of auditory perception and plasticity. To this end, we study how neurons in the auditory cortex process acoustic inputs, using electrophysiological, anatomical, behavioral and molecular methods. Our current research addresses two main questions: 1. What is the cellular basis of the functional organization of auditory cortex? 2. What role do acetylcholine receptors play in the development and function of auditory cortex? Our ultimate goal is to achieve an understanding — integrated from molecular to cellular to systems and behavioral levels — of the role of auditory cortex and its regulation in higher brain function.

John Middlebrooks
Professor, Depts. of Otolaryngology, Neurobiology & Behavioral, Cognitive Sciences, and Biomedical Engineering

My research involves spatial hearing and auditory prosthesis. The spatial hearing work explores the brain mechanisms by which a listener can segregate competing sounds that originate from multiple locations. Our perceptual studies demonstrate that this “spatial stream segregation” exhibits a high degree of spatial resolution and that the dominant spatial cues are differences in the time of arrival of sounds at the two ears. Our physiological studies in animals demonstrate that perceptually segregated streams sounds correspond to activity in discrete populations of neurons in the auditory cortex. The auditory-prosthesis project involves development of a penetrating auditory-nerve electrode array intended to stimulated the auditory pathway in deaf patients. Short-term implantations in animals demonstrate many benefits of this approach compared to a conventional cochlear implant. Our ongoing experiments will test safety and efficacy of long-term implantation in animals prior to initial human trials.

Khaleel A. Razak
Associate Professor, Psychology, UC Riverside

Interests: 1. Cortical mechanisms of sound localization. 2. Cortical plasticity during aging and hearing loss. 3. Mechanisms underlying auditory cortical processing deficits in Fragile X Syndrome.

Virginia Richards
Professor, Cognitive Sciences

Interests: Auditory perception and cognition, and human psychophysics.

Edwin W. Rubel
Visiting Professor (Winter quarter, annually), Anatomy and Neurobiology

Interests: Auditory physiology and development.  Genetic and small molecule studies to prevent hair cell loss and stimulate hair cell regeneration.

Kourosh Saberi
Professor, Cognitive Sciences

Interests: Signal detection & Psychophysics, Cortical Neuroscience, Hearing Research, Music Perception, Cortical bases of sensory and perceptual processes.

Steven Small
Professor and Chair, Neurology

Our laboratory uses functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), high density electroencephalography (hd-EEG), and transcranial magnetic stimulation (TMS) to study the organization of the normal human cerebral cortex and the changes that it undergoes after neurological injury, particularly stroke.
We focus particularly on speech, language, and hand motor function. In the study of normal adults, we have found that the language areas of the brain are more widely distributed than previously thought, extending to brain regions that are anatomically removed from those originally postulated by Broca, Wernicke, and Déjérine, and extending to both cerebral hemispheres. In our studies of stroke recovery of speech, language, and hand motor function, we perform longitudinal behavioral testing and brain imaging during natural recovery and during treatment interventions. During natural recovery, we have shown that patients’ performance improves and their pattern of brain activity changes, and that the hemisphere ipsilateral to the injury and the cerebellum contralateral to the injury play the major role in recovery. Various intervention studies are in progress, both for aphasia and hand motor recovery, and these studies aim to take advantage of the process of observation-execution matching, the human analogue to the macaque mirror neuron system, to improve function after stroke and the understand the brain mechanisms of recovery.

Ramesh Srinivasan
Associate Professor, Cognitive Sciences

Interests: Cognitive Neuroscience, Brain Development, Consciousness, Perception, EEG, Brain Dynamics.

Arne Starr
Research Professor, Neurology, Neurobiology & Behavior, Cognitive Sciences

Interests: We are investigating the neurobiological bases of clinical disorders of the nervous system that affect sensation, motor performance, and cognition. Our studies employ electrophysiological and behavioral methods to define functional mechanisms underlying clinical syndromes relevant for specific research question. We study altered auditory processes in normal subjects and in 1) auditory neuropathy, a disorder of auditory nerve function in the presence of normal hair cell functions; 2) auditory memory and attention and changes with aging and dementias. We use physiological brain potentials measures of auditory pathway activity from the hair cell to auditory cortex to localize the site of change in the auditory pathway.

William Tang
Associate Dean for Research, Henry Samueli School of Engineering
Professor, Biomedical Engineering and Electrical Engineering and Computer
Science

Interests: Our research focuses on applications of microscale and nanoscale engineering for information technology and biomedical sciences. We are initiating new projects in ultra-low-power, high-Q and high-frequency resonators for wireless communications and signal processing, biological fuel cells and single-cell physiology and engineering.

Frederic Wan
Professor, Mathematics

Interests:  signal processing

Brian J-f Wong
Professor and Vice Chairman, Otolaryngology- Head and Neck

My research areas include shape change in tissue, optical coherence tomography, cartilage biomechanics, and surgical device development. Clinically, my practice is in Facial Plastic Surgery with specific expertise in Rhinoplasty.

Jack Xin
Professor, Mathematics

Interests: Partial Differential Equations, Asymptotic Analysis, Scientific Computation, and their Applications. Fronts in heterogeneous media, ear modeling, and sound signal processing.

Xiangmin Xu
Assistant Professor, Anatomy & Neurobiology

Interests: We are interested in neural circuitry, which applies to understanding the neurobiology of sensory perception, learning and memory, and epilepsy. Understanding how neural circuits give rise to perception, cognition, and behavior is central to understanding how the brain works. This is also key to understanding the mechanistic basis of neurological disorders.

Fan-Gang Zeng
Professor, Otolaryngology, Anatomy and Neurobiology, Biomedical
Engineering, and Cognitive Sciences

Interests: Cochlear Implant, Auditory Neuroscience, Psychophysics, Speech Perception, Auditory Neuropathy. Use systems and modeling approach to understand how the ear and the brain work together to process sounds, including human speech and music. Develop and design innovative prosthetic devices and training procedures for people who have lost hearing and balance functions.

HongKai Zhao
Professor, Mathematics

Interests:  signal processing

 

 

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CHR Membership bylaws

1. CHR is inclusive, not exclusive. Accordingly, the election of new members to CHR requires only (a) a nomination from an existing member, and (b) the proposed member acknowledging a desire to join the membership of CHR.

2. The membership of the CHR will be polled annually to determine their interest in retaining their membership. It will be assumed that unless the member indicates a preference to be dropped from membership, membership will be maintained.